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If you have reached Act 6.4.1 , congratulations. You are past the nightmare of The Champion (6.2.5) and the toxicity of the Caustic Tempo nodes. But 6.4.1 still has a nasty reputation thanks to its Global Node: Backblast (taking damage when your Special Attacks are blocked).

Start → Mutant Gate → Skill Gate → Tech Gate → Boss (Mysterio)